99%+ Purity
COA Included
Sealed Vials
PNC-27
Cancer cell targeting peptide
Cancer cell targeting peptide
Key Benefits
- Selective cancer cell targeting mechanism
- Rapid cellular action within hours
- Multiple cancer cell line compatibility
- Minimal normal cell interaction observed
- Dual-action binding and disruption technology
- Works regardless of p53 status
- Precision HDM-2 surface marker recognition
About PNC-27
PNC-27 represents a breakthrough approach in cancer research, combining cutting-edge peptide science with precision targeting technology. This innovative 32-amino acid synthetic peptide may support selective cancer cell targeting by recognizing HDM-2 proteins that become abnormally expressed on cancer cell surfaces—a unique molecular signature that distinguishes malignant cells from healthy tissue. Research suggests PNC-27's dual-action mechanism first binds specifically to these surface markers, then activates membrane-disrupting properties derived from bee venom components to potentially compromise cancer cell integrity. Studies indicate this targeted approach may affect various cancer cell types including breast, pancreatic, and melanoma cells while leaving normal cells largely unaffected, since healthy cells typically don't express significant HDM-2 levels on their surface. The peptide's selectivity mechanism represents a promising research direction for those seeking advanced, scientifically-grounded approaches to cancer cell targeting, with preclinical evidence suggesting rapid action within hours of treatment across multiple cancer cell lines.
Research Background
PNC-27 represents an innovative approach to cancer therapy by targeting a protein called HDM-2 that becomes abnormally expressed on cancer cell surfaces. In healthy cells, HDM-2 normally functions inside the cell to regulate p53, often called the "guardian of the genome" for its role in preventing cancer. However, many cancer cells display HDM-2 on their outer membrane, creating a unique molecular signature that PNC-27 can recognize and bind to.
The peptide combines two functional components: (1) a targeting sequence that specifically binds to HDM-2, and (2) a membrane-disrupting sequence derived from bee venom that can create holes in cell membranes. When PNC-27 binds to HDM-2 on cancer cells, it activates the membrane-disrupting component, leading to selective cancer cell death while leaving normal cells largely unaffected. Current research focuses on understanding which cancer types express the highest levels of surface HDM-2, optimizing treatment protocols, and investigating combination approaches with other cancer therapies.
Compliance & Disclaimer
This product is intended for laboratory research purposes only. Not for human consumption. All products are sold with the understanding that the purchaser will comply with all applicable local, state, and federal laws regarding the purchase and use of research chemicals. Certificate of Analysis available upon request.
PNC-27
$125.00